KMID : 0361120210350010048
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Korean Journal of Transplantation 2021 Volume.35 No. 1 p.48 ~ p.52
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Posttransplantation tuberculosis management in terms of immunosuppressant cost: a case report in Myanmar
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Lwin Phyo Wai
Htun Yi Yi Myint Aung Kyaw Swe Htar Kyi
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Abstract
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Drug interactions between anti-tuberculosis and immunosuppressive medications after renal transplantation are a common problem in Myanmar. The efficacy of both types of drugs can be reduced during the treatment period, which can lead to graft failure and flare-ups of infection. Drug adjustments, with frequent monitoring and close follow-up, are crucial in this period. Ketoconazole decreases tacrolimus metabolism by inhibiting cytochrome P450-3A5 enzymes and P-glycoprotein. It is cost effective and has been frequently used to reduce the dose and cost of tacrolimus. Here, we report the case of a 56-year-old male renal transplant recipient with anti-tuberculosis medications.
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KEYWORD
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Post renal transplant tuberculosis, Immunosuppressant cost, Drug Interaction
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